miRNA mimics & inhibitors

microRNA(miRNA) is a type of endogenous small non-coding RNA in eukaryotes with a length of about 17~25nt. Since the discovery of miRNAs in 1993, the advances and discoveries of small RNA have upended the scientific understanding of gene regulation. From embryonic development to apoptosis, and tumor growth, miRNAs play an important role in a range of physiological and pathological processes, and various miRNAs related to genetics, metabolism, infectious diseases or tumors have presented a new perspective for scientists to conduct pathological research, and it may become a reliable biomarker for disease. Scientists are also actively changing the function of miRNA and developing new in vivo delivery methods to seek interventions. Recently, miRNAs have been used to mediate the cross-specie evolution and adaptation.

micrON™ miRNA mimic are chemically synthesized miRNA mimics, it can simulate the high level expression of mature miRNAs in cells to enhance the regulation of endogenous miRNA for the gain-of-function study. MiRNA mimic is a simple and efficient tool for miRNA research, it can be transfected into cells with transfection reagent without constructing the vector, and the transfection efficiency can be studied through transfection control. RiboBio provides all the miRNA mimics of human, mouse and rat from the latest miRBase database and keeps replenishing the stocks, the miRNA mimic of other species needs to be customized with a minimum order quantity of 10nmol.

micrOFF™ miRNA inhibitor is a chemically synthesized and specially modified miRNA inhibitor, it inhibits the function of mature miRNA molecules with the combined specificity and downplay the regulation of miRNA in cells. The miRNA loss-of-function studies are commonly used to screen miRNA target sites, screen miRNAs that regulate the expression of a gene, or miRNAs that affect cell growth and proliferation.

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